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作者通过对鼠疫疫区和非疫区阿拉善黄鼠实验感染鼠疫的研究得出:疫区黄鼠感染后死亡上下限相差100 000倍,非疫区黄鼠感染后死亡上下限相差1000倍,表明疫区黄鼠对鼠疫菌具有较高的自然抗性。在实验条件下疫区冬眠黄鼠呈迁延性带菌过程。非疫区黄鼠相对表现出对鼠疫菌的高感受高敏感状态,未发现存活鼠有迁延性带菌过程,存活鼠血清也未查到鼠疫F1抗体。通过这次实验更进一步证实青海省海东地区的黄鼠目前还不具备鼠疫贮存宿主的基本条件。在实验条件下发现黄鼠能带菌越冬,这再次为鼠疫保存机理的研究提供了线索和资料依据。研究结果还表明黄鼠感染鼠疫菌后的主要表现为发病急,潜伏期大多数为1～2天,最短的为12小时,食欲不振,背毛竖立,呼吸急促,3天后注射部位有淋巴结肿大。其病理改变主要为出血性炎症反应,随着攻毒剂量的增加病理改变也随之严重,攻毒剂量小的则以增生性变化为主,攻毒剂量大的以渗出、出血和坏死变化为主。
The author of the plague epidemic and pest free area Alzheimer’s disease experimental plague infected plague found that: the infected area of the cholera after the death of the upper and lower limits of a difference of 100 000 times the dead chlamydia in the pest free area difference of 1000 times, It shows that the infected yellow spot rat has high natural resistance to Yersinia pestis. Under the experimental conditions, the hibernating zooplankton in the epidemic area showed a persistent bacterial process. Relatively high susceptibility to Yersinia pestis in the pest free area was relatively high, and no persisting carriage of surviving mice was found. Survival rat sera also failed to detect the plague F1 antibody. This experiment further confirmed that the yellow rat in Haidong, Qinghai Province does not yet have the basic conditions for plague host storage. Under the experimental conditions, it has been found that the gonads can carry the bacteria overwintering, which provides clues and data basis for the study of the mechanism of plague storage again. The results also showed that the main manifestation of the infection of plague rats after the onset of acute, most of the incubation period of 1 to 2 days, the shortest of 12 hours, loss of appetite, back hair erection, shortness of breath, three days after the injection site with lymph nodes . The main pathological changes were hemorrhagic inflammation, with the increase of the dose of the pathological changes also will be serious, the small dose of the attack is based on proliferative changes, a large dose of bleeding to bleeding, bleeding and necrosis changes Mainly.