与静注抗生素比较,口服Ciprofloxacin显示类似的抗感染疗效,但费用要少得多。静注抗生素治疗重症细菌性感染72小时后,99例年过65岁的住院患者中随机分配49例继续静注抗生素治疗,余50例改用每天2次,每次口服Ciprofloxacin750mg治疗。Ciprofloxacin组有8例患者还给予口服灭滴灵。在治疗前、中、后作了细菌培养和实验室试验,每例患者抗生素治疗至少8天。最后一剂抗生素治疗后随访2—6周。 Compared with intravenous antibiotics, oral Ciprofloxacin showed a similar anti-infective effect, but at a much lower cost. After 72 hours of intravenous antibiotics for treatment of severe bacterial infections, 99 patients 65 years of age were randomized to continue antibiotic therapy in 49 patients and the remaining 50 patients switched to oral Ciprofloxacin 750mg twice daily. Eight patients in the Ciprofloxacin group were also given oral metronidazole. Bacterial culture and laboratory tests were performed before, during, and after treatment, with antibiotic treatment for at least 8 days in each patient. The last dose of antibiotic was followed up for 2-6 weeks.