端粒酶的活性往往伴随着培养细胞的永生化 ,也是肿瘤细胞中的一个普遍的特征。自Ｃｏｕｎｔｅｒ等人在人类卵巢癌中检出端粒酶活性和Ｋｉｍ创建了端粒酶活性的ＴＲＡＰ ＰＣＲ检测方法以来 ,端粒酶的研究已成为人类肿瘤诊断和治疗的新热点。1　端粒酶的发现真核细胞线状染色体 Telomerase activity is often accompanied by immortalization of cultured cells and is a common feature in tumor cells. Since Count et al. detected telomerase activity in human ovarian cancer and Kim created a TRAP PCR assay that created telomerase activity, the study of telomerase has become a new hot spot in the diagnosis and treatment of human tumors. 1 Telomerase discovery eukaryotic linear chromosome