溶瘤腺病毒是一组通过基因工程构建的腺病毒、能够选择性在肿瘤细胞中完成感染-复制周期,从而特异性地杀伤、溶解肿瘤而不伤及其他正常细胞、组织,其作用机制包括:通过基因的缺失突变、插入特异性启动子、以及通过病毒结构蛋白的修饰等方面,实现肿瘤靶向治疗作用。本文就相关研究及进展进行综述。 Oncolytic adenovirus is a group of genetically engineered adenovirus that selectively completes the infection-replication cycle in tumor cells to specifically kill and lyse the tumor without damaging other normal cells and tissues, and its mechanisms of action include : Through the deletion of mutations in genes, insertion of specific promoters, and through the modification of viral structural proteins and other aspects, to achieve tumor-targeted therapeutic effect. This article reviews related research and progress.