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目的:通过前瞻对照研究氯氮平治疗的精神分裂症病人其血沉的变化情况,找出血沉变化的特点。 方法:病例入组后男女病人分别按年龄、性别随机分为氯氮平组(观察组)和氯丙嗪组(对照组)。于用药前及用药后一、二、三、四、五周末分别查血沉一次,另设正常对照组观察健康女性月经来潮时血沉变化情况以排除月经期血沉生理变化对实验的影响。 结果:20例服用氯氮平治疗的病人血沉异常15例(75％),血沉最高为50mm/h,21例氯丙嗪治疗的病人血沉异常1例(4.76％)。两组具有统计学极显著差异(x~2=21.24,P<0.005)。血沉异常一般于用药后一周内达最高值,此后逐渐降低,大部分(13例)于第五周末降至正常范围。 结论:氯氮平对血沉影响的研究未见报道。本研究显示用氯氮平治疗者血沉异常率为75％％,表明血沉一过性异常是氯氮平的又一副作用,此副作用出现后不需停药及特殊处理。这一现象的发现有利于进一步了解氯氮平的药理作用。
OBJECTIVE: To investigate the changes of erythrocyte sedimentation rate (ESR) in schizophrenic patients treated with clozapine through a prospective, controlled study. Methods: Male and female patients were randomly divided into clozapine group (observation group) and chlorpromazine group (control group) according to their age and sex. Before treatment and medication after one, two, three, four, five were the end of blood sedimentation time, another set of normal control group observed healthy women menstrual cramps changes in ESR to rule out menstrual ESR changes on the experiment. Results: Erythrocyte sedimentation rate was 50 mm / h in 20 cases of patients taking clozapine, and 1 case (4.76%) in 21 cases treated with chlorpromazine. The two groups had statistically significant differences (x ~ 2 = 21.24, P <0.005). Erythrocyte abnormalities generally reached the maximum value within a week after treatment, then gradually decreased, the majority (13 cases) fell to the normal range in the fifth weekend. Conclusion: The study of clozapine on erythrocyte sedimentation rate has not been reported. This study showed that the rate of erythrocyte sedimentation rate was 75 %% with clozapine treatment, indicating that an abnormal erythrocyte sedimentation rate is another side effect of clozapine. This side effect does not require discontinuation and special treatment after emergence. The discovery of this phenomenon is conducive to further understanding of the pharmacological effects of clozapine.