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葡萄糖转运蛋白4(glucose transporter 4,GLUT4)是胰岛素响应组织骨骼肌和脂肪组织内负责葡萄糖吸收的转运蛋白,它与生物体糖代谢过程密切相关.在肥胖或以胰岛素抵抗为特征的2型糖尿病等代谢性疾病中,GLUT4功能受损;反之,GLUT4功能的变化也能影响整体的糖代谢水平.本文概述了GLUT4的功能、组织分布、功能调节方式以及调控GLUT4功能的小分子化合物的研究进展,讨论了GLUT4在其他疾病中的应用,并展望了其未来研究方向.
Glucose transporter 4 (GLUT4) is a transporter responsible for glucose uptake in skeletal muscle and adipose tissue of insulin-responsive tissues and is closely related to the process of glucose metabolism in the body.In type 2 diabetes, characterized by obesity or insulin resistance And other metabolic diseases, GLUT4 function impaired; Conversely, changes in GLUT4 function can also affect the overall level of glucose metabolism.This paper summarizes the GLUT4 function, tissue distribution, functional regulation and regulation of GLUT4 function of small molecule compounds research progress , Discussed the application of GLUT4 in other diseases and looked forward to its future research direction.