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目的观察进展性脑梗死与血浆同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)的关系。方法测定神经内科住院的32例进展性脑梗死患者(观察组)及37例非进展性脑梗死患者(对照组)的血浆Hcy及hs-CRP水平,收集患者的人口学、血管性危险因素资料,评估患者的卒中类型和病情程度。结果与对照组相比,观察组的低密度脂蛋白胆固醇水平显著高、完全前循环梗死比例高、美国国立卫生院神经功能缺损评分(NIHSS)显著高、血浆Hcy及hs-CRP水平亦显著升高(P<0.05)且在观察组中两者呈正相关(r=0.414,P=0.019)。结论进展性脑梗死患者的血浆Hcy及hs-CRP的水平高。
Objective To observe the relationship between progressive cerebral infarction and plasma homocysteine (Hcy) and high sensitivity C reactive protein (hs-CRP). Methods Plasma Hcy and hs-CRP levels were measured in 32 patients with progressive cerebral infarction (observation group) and 37 patients with non-progressing cerebral infarction (control group) hospitalized in neurology department. The demographic and vascular risk factors , Assess the patient’s stroke type and severity. Results Compared with the control group, the observation group had significantly higher LDL-C levels, a higher proportion of complete anterior circulation infarction, a significant increase in NIHSS, and a significant increase in plasma Hcy and hs-CRP levels (P <0.05), and there was a positive correlation between them in the observation group (r = 0.414, P = 0.019). Conclusions Plasma Hcy and hs-CRP levels are elevated in patients with progressive cerebral infarction.