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目的检测增殖细胞核抗原(PCNA)在上皮性卵巢肿瘤中的表达。方法应用免疫组化S-P法。结果72例上皮性卵巢肿瘤中良性12例,交界性17例,恶性43例。在三组肿瘤中,PCNA的表达率分别为250%、588%及884%(P<001)。在恶性组中,PCNA的表达率与临床期别和细胞分化程度呈正相关。结论检测PCNA可作为临床卵巢癌诊断和判断预后的辅助指标
Objective To detect the expression of proliferating cell nuclear antigen (PCNA) in epithelial ovarian tumors. Methods Using immunohistochemical S-P method. Results 72 cases of benign epithelial ovarian tumors in 12 cases, 17 cases of borderline, 43 cases of malignant. The expression rates of PCNA in three groups of tumors were 25.0%, 58.8% and 88.4%, respectively (P <001). In malignant group, PCNA expression rate and clinical stage and the degree of cell differentiation was positively correlated. Conclusion The detection of PCNA can be used as an auxiliary index for the diagnosis and prognosis of clinical ovarian cancer