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目的:研究马来酸罗格列酮在不同激发光波长以及不同酸碱度条件下的表面增强拉曼光谱,对表面增强拉曼光谱中的分子振动模式进行识别。方法:用3种不同的激发光波长对不同pH条件下马来酸罗格列酮的表面增强拉曼散射(SERS)进行考察,推测分子在纳米颗粒上的吸附取向、成键方式,对增强机制作出推断。结果:研究表明,药物分子-银胶体系的pH对马来酸罗格列酮的增强效应有较大的影响,这是pH对药物分子-银胶体系的凝聚状态和马来酸罗格列酮分子存在状态综合影响的结果。另外,激发光波长对马来酸罗格列酮的SERS效应也有很大的影响,这体现了光源对药物分子-银胶体系的选择性激发。结论:本方法简单、快速、可靠,专属性强,可以作为分析马来酸罗格列酮分子在纳米表面吸附情况的方法。
OBJECTIVE: To study the surface-enhanced Raman spectra of rosiglitazone maleate under different excitation wavelengths and different pH conditions, and to identify molecular vibration modes in surface-enhanced Raman spectra. Methods: The surface-enhanced Raman scattering (SERS) of maleic acid rosiglitazone at different pHs was investigated by using three different excitation wavelengths. The adsorption orientation and bonding mode of the molecules on the nanoparticles were estimated. The enhancement mechanism Make inferences. Results: The results show that the pH value of the drug molecule-silver colloid system has a greater effect on the enhancing effect of rosiglitazone maleate, which is the effect of pH on the aggregation state of drug molecule-silver colloid system and rosiglitazone maleate The combined effect of the presence of ketone molecules results. In addition, the SERS effect of rosiglitazone maleate is greatly affected by the wavelength of the excitation light, which reflects the selective excitation of the light source on the drug molecule-silver colloid system. Conclusion: The method is simple, rapid, reliable and specific. It can be used as a method to analyze the adsorption of rosiglitazone maleate on the surface of nano-scale.