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目的:探讨肺部恶性肿瘤患者小气道功能与气道高反应之间的关系。方法:通过建立数据库,对2010-2013年肺癌住院患者信息进行分析,运用t检验和直线相关分析小气道功能指标与气道反应性和敏感性指标间的相关关系。结果:从激发试验阳性组与阴性组肺功能比较来看,阳性率较低,两组FEF 25%、FEF 50%间的差异有统计学意义(P<0.05),而VC、FVC、FEV1、FEF 75%、MMEF25/75、PEF的差异无统计学意义(P>0.05);从小气道功能正常与异常组间气道反应性和敏感性指标比较来看,小气道功能反应性和敏感性较好,Rrs、Grs、Dmin、PD35的差异有统计学意义(P<0.05。结论:肺癌患者存在小气道功能障碍,小气道功能检测对肺部恶性肿瘤患者术前检查有着重要意义。
Objective: To investigate the relationship between small airway function and airway hyperresponsiveness in patients with lung cancer. Methods: The data of inpatients with lung cancer from 2010 to 2013 were analyzed by establishing a database. The correlation between the indexes of airway function and airway responsiveness and sensitivity was analyzed by t test and linear correlation analysis. Results: Compared with the pulmonary function test in positive group and negative group, the positive rate was lower, the difference between FEF 25% and FEF 50% was statistically significant (P <0.05), while the VC, FVC, FEV1, FEF 75%, MMEF25 / 75 and PEF had no significant difference (P> 0.05). From the comparison of airway responsiveness and sensitivity between small airway function normal group and abnormal group, small airway function reactivity and sensitivity The difference of Rrs, Grs, Dmin and PD35 was statistically significant (P <0.05) .Conclusion: There are small airway dysfunction in patients with lung cancer, and the detection of small airway function is of great significance for preoperative examination of patients with lung cancer.