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目的检测血流介导的血管扩张(FMD)、脉搏波传导速度(PWV)和颈动脉内膜中层厚度(CIMT),探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与动脉粥样硬化之间的关系。方法对76例OSAHS患者(OSAHS组)及76例年龄、性别、体重指数与之相匹配患者(对照组)进行FMD、PWV和CIMT检测,对两组间FMD、PWV和CIMT值进行比较,对OSAHS组睡眠呼吸暂停低通气指数(AHI)与FMD、PWV和CIMT之间关系进行相关性分析。结果OSAHS组PWV[(1720±247)cm/s]、CIMT[(1.10±0.34)mm]显著高于对照组[(1469±172)cm/s、(0.80±0.18)mm],FMD[(5.8±1.7)%]显著低于对照组[(8.9±1.4)%,P均<0.01];比较两组中所有伴高血压者,OSAHS组PWV、CIMT[(1850±244)cm/s、(1.24±0.35)mm]仍显著高于对照组[(1655±161)cm/s、(0.99±0.18)mm,P=0.001、0.003],FMD[(5.2±1.7)%]显著低于对照组[(7.5±1.1)%,P<0.01];OSAHS组AHI值与PWV、CIMT值呈正相关(r=0.883、0.698,P均<0.01),与FMD值呈负相关(r=-0.711,P<0.01)。结论OSAHS患者存在更为明显的内皮功能障碍及动脉粥样硬化,且与OSAHS严重程度有关。
Objective To investigate the relationship between blood flow-mediated vasodilation (FMD), pulse wave velocity (PWV) and carotid artery intima-media thickness (CIMT) and to investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and atherosclerosis Relationship between. Methods FMD, PWV and CIMT were measured in 76 patients with OSAHS (OSAHS group) and 76 patients with matched age, sex and body mass index (control group). The FMD, PWV and CIMT values were compared between the two groups. OSAHS group sleep apnea-hypopnea index (AHI) and FMD, PWV and CIMT correlation analysis. Results Compared with control group, PWV [(1720 ± 247) cm / s and CIMT [(1.10 ± 0.34) mm] in OSAHS group were significantly higher than those in control group [(1469 ± 172) cm / 5.8 ± 1.7)%] were significantly lower than those in the control group [(8.9 ± 1.4)%, P <0.01 respectively]; PWV and CIMT [1850 ± 244] cm / s in OSAHS group were significantly higher than those in OSAHS group (1.24 ± 0.35) mm] was significantly higher than that of the control group [(1655 ± 161) cm / s, (0.99 ± 0.18) mm, P = 0.001,0.003] (P <0.01). There was a positive correlation between AHI and PWV and CIMT in OSAHS group (r = 0.883,0.698, P <0.01), and was negatively correlated with FMD (r = -0.711, P <0.01). Conclusion There is more obvious endothelial dysfunction and atherosclerosis in OSAHS patients, which is related to the severity of OSAHS.