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有机磷农药由于杀虫效果高,对防治病虫害、促进农业生产等方面均起了相当大的作用,现已在农业生产上广泛使用。但它对人畜的毒性也很大,若使用不当、保管不妥,极易造成人畜中毒,值得重视。一、中毒作用机理:当有机磷农药进入人体后,其磷酰根部分与胆碱酯酶结合成为不易水解的磷酰化胆碱酯酶,抑制了胆碱酯酶的活动,使乙酰胆碱不能水解,而在人体组织中大量堆积,致使整个胆碱反应系统过度兴奋,最后可转入抑制和衰
Due to its high insecticidal effect, organophosphorus pesticides play a significant role in pest control and agricultural production promotion and are now widely used in agricultural production. However, it is also very toxic to humans and animals. If used improperly and improperly stored, it is highly likely to cause human and animal poisoning, which deserves attention. First, the toxic mechanism of action: When organophosphorus pesticides into the human body, the phosphorylation of some of their phosphorus and choline esterase into less easily hydrolyzed phosphoryl cholinesterase, inhibition of cholinesterase activity, so that acetylcholine can not be hydrolyzed , While a large number of accumulation in human tissues, resulting in over-excitement of the entire choline reaction system, and finally into the suppression and failure