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板蓝根注射液常有微量烟雾状沉淀产生(俗称冒烟)。我们曾先后采用加抗氧剂、调注射液的pH、加滑石粉吸附和加热灭菌后冷藏等方法,效果均不理想。后对板蓝根注射液中间体重新加氨、脱氨,试验得到较为满意的效果,现介绍如下。一、方法:取板蓝根中间体,即板蓝根生药材经水煎酒沉,加氨、脱氨后供配制注射液的水溶液,加药液体积1~2%的浓氨水使之pH达8.5~9,冷藏2小时,过滤后加热迴流
Banlangen injection often produces traces of smoke-like deposits (commonly known as smoke). We have used antioxidants, adjusting the pH of injections, adding talcum powder, and sterilizing after heat sterilization. The effect is not ideal. After the re-addition of ammonia and deamination to the Banlangen injection intermediate, a satisfactory result was obtained. The results are as follows. First, the method: take Banlangen intermediate, that is, Banlangen raw materials by water decoction, add ammonia, deamination after preparation of the aqueous solution for injection, plus the liquid volume of 1 ~ 2% concentrated ammonia to make the pH reach 8.5 ~ 9 , refrigerated for 2 hours, filtered and heated to reflux