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目的探讨他汀类药物对轻度胆固醇升高的老年冠心病患者冠状动脉粥样硬化斑块的影响。方法选择我院收治的112例冠状动脉粥样硬化老年患者,分为治疗组和对照组各56例,治疗组给予他汀类药物治疗,对照组患者给予非他汀类药物,比较两组患者治疗前后的LDL-C、HDL-C、hs-CRP以及冠脉斑块大小、斑块厚度和斑块数量。结果治疗后LDL-C和hs-CRP较治疗前均显著降低,组间差异有统计学意义(P<0.05),治疗组HDL-C较治疗前显著升高,但对照组较治疗前升高无显著性差异;治疗前两组患者的斑块大小、斑块厚度和斑块数量均无显著性差异,治疗后均显著降低,治疗组显著低于对照组(P<0.05)。结论他汀类药物能使轻度胆固醇升高的老年冠心病患者冠状动脉粥样硬化斑块的体积明显缩小,数量明显减少,是治疗冠状动脉粥样硬化的理想药物
Objective To investigate the effect of statins on coronary atherosclerotic plaques in elderly patients with coronary heart disease with elevated cholesterol. Methods A total of 112 elderly patients with coronary atherosclerosis admitted to our hospital were divided into treatment group (56 cases) and control group (56 cases). Patients in the treatment group were given statins and patients in the control group were given non-statin drugs. Before and after treatment Of LDL-C, HDL-C, hs-CRP and coronary plaque size, plaque thickness and plaque number. Results After treatment, LDL-C and hs-CRP were significantly lower than before treatment, the difference between the two groups was statistically significant (P <0.05), the treatment group HDL-C was significantly higher than before treatment, but the control group than before treatment increased There was no significant difference between the two groups before treatment. There was no significant difference in plaque size, plaque thickness and plaque number between the two groups before treatment. After treatment, the two groups were significantly lower than the control group (P <0.05). Conclusion Statins can make the volume of coronary atherosclerotic plaques in elderly patients with coronary heart disease with slightly elevated cholesterol significantly reduce and significantly reduce the volume of coronary atherosclerosis, which is the ideal drug for the treatment of coronary atherosclerosis