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目的 分析慢性乙型肝炎抗 -HBe阳性与HBV -DNA检出关系。方法 采用斑点杂交法检测101例抗 -HBe阳性的慢性乙型肝炎患者HBV -DNA。结果 HBV -DNA阳性36例 ,阳性率35.64% ,HBV -DNA阳性检出率 ,以慢性重型肝炎最高 ,其次慢性乙型肝炎重度、中度患者 ,轻度慢性乙型肝炎最低。检出率随着病程的延长而升高。 结论 表明抗 -HBe阳转 ,体内HBV -DNA并未彻底清除 ,HBV的持续存在是变异发生的基础。
Objective To analyze the relationship between anti-HBe positive in chronic hepatitis B and HBV-DNA. Methods Dot blot hybridization was used to detect HBV-DNA in 101 anti-HBe positive chronic hepatitis B patients. Results The positive rate of HBV DNA in 36 cases was 35.64%. The positive rate of HBV DNA was the highest in chronic severe hepatitis, followed by the lowest in severe and moderate chronic hepatitis B patients and mild chronic hepatitis B patients. The detection rate increased with the duration of the disease. Conclusions show that anti-HBe positive, HBV-DNA in vivo is not completely cleared, the persistence of HBV is the basis of the mutation.