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目的:探讨慢性阻塞性肺部疾患(COPD)和支气管哮喘患者及对照组细胞免疫与肺通气功能的改变及其相关关系。方法:分別对急性期的20例COPD患者、18例哮喘患者和18例正常人采血用流式细胞术测其CD_3~+、CD_3~+CD_4~+、CD_3~+CD_8和NK细胞,并测定肺功能。结果:哮喘组与对照组比较CD_3~+和CD_3~+CD_8~+均下降,NK细胞百分比降低;COPD组CD_3~+和CD_3~+CD_4~+均下降,NK细胞百分比也下降。哮喘以阻塞性通气功能障碍为主,COPD以混合性通气功能障碍和限制性通气功能障碍为主。结论:哮喘和COPD患者细胞免疫失衡和肺功能改变不同,提示两者发病机理不同。
Objective: To investigate the changes of cellular immunity and pulmonary ventilation in chronic obstructive pulmonary disease (COPD) and bronchial asthma patients and the control group and their correlations. Methods: The blood samples of 20 patients with COPD, 18 patients with asthma and 18 healthy controls were collected for the determination of CD_3 ~ +, CD_3 ~ + CD_4 ~ +, CD_3 ~ + CD_8 and NK cells by flow cytometry Pulmonary function. Results: Compared with the control group, the levels of CD_3 ~ + and CD_3 ~ + CD_8 ~ + decreased and the percentage of NK cells decreased in the asthma group. The percentage of CD_3 ~ + and CD_3 ~ + CD_4 ~ + decreased and the percentage of NK cells decreased in COPD group. Asthma is dominated by obstructive ventilatory dysfunction, which is dominated by mixed ventilatory dysfunction and restrictive ventilatory dysfunction. Conclusion: The cellular immune imbalance and pulmonary function changes in patients with asthma and COPD are different, suggesting that the pathogenesis of the two are different.