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目的：建立肝纤维化血清学诊断谱，并探讨其在肝纤维化诊断与疗效考核中的意义。方法：用四氯化碳诱导大鼠产生肝纤维化动物模型，动态测定多种血清学指标。经筛选，确定血清有机膦酸酯酶（ＰＥ）、一氧化氮（ＮＯ）、Ⅲ型前胶原（ＰＣⅢ）与透明质酸（ＨＡ）四种指标为联合检测谱。在此基础上，测定了１７１例急、慢性肝病患者这四种指标的变化。结果：随着肝纤维化程度的加深，这些血清学指标也相应逐渐升高，四种指标联合检测的敏感性为９６％～９８％，特异性为８９％。而在抗肝纤维化治疗后，这一诊断谱也相应降低。结论：该血清学诊断谱可作为肝纤维化诊断与评估抗肝纤维化疗效的指标
Objective: To establish a serological diagnostic spectrum of liver fibrosis and to explore its significance in the diagnosis and therapeutic evaluation of liver fibrosis. Methods: The animal model of liver fibrosis was induced by carbon tetrachloride, and various serological indexes were measured dynamically. After screening, the four indexes of serum organic phosphoneridase (PE), nitric oxide (NO), type Ⅲ procollagen (PCⅢ) and hyaluronic acid (HA) were determined. On this basis, the changes of these four indexes in 171 patients with acute and chronic liver diseases were measured. Results: With the deepening of liver fibrosis, these serological indicators also gradually increased, the sensitivity of the four indicators combined detection was 96% to 98%, the specificity of 89%. In the anti-fibrosis treatment, the corresponding reduction in the diagnostic spectrum. Conclusion: This serological diagnostic spectrum can be used as an index to diagnose and evaluate the therapeutic effect of liver fibrosis