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目的了解章丘市新生儿接种5ug重组乙型肝炎疫苗后应答情况,并分析影响因素。方法对477名7~12月龄、按照国家0、1、6免疫程序完成5ug重组乙型肝炎疫苗初免的婴儿,用化学发光微粒子免疫分析法(CMIA)和美国雅培ARCHITECT-i 2000免疫发光检测仪及其试剂,定量检测乙肝病毒表面抗体(抗-HBs)。结果 477名新生儿检测显示,血清抗-HBs滴度最小值为1.14m IU/ml,最大值为6 721.36 m IU/ml,几何平均浓度(GMC)为593.89 m IU/ml。无应答率为3.14%,低应答率为23.27%。不同性别、是否足月产、不同出生体重儿童接种疫苗后均能产生较高的应答率,差异无统计学意义(χ~2=1.25,P>0.05;χ~2=2.53,P>0.05;χ~2=1.77,P>0.05),而母亲Hbe Ag携带状况与新生儿接种乙肝疫苗后低无应答有关(χ~2=9.26,P<0.01)。结论章丘市新生儿接种5ug重组乙型肝炎疫苗后低无应答率为26.42%。母亲Hbe Ag携带状况对乙肝疫苗免疫效果有影响。
Objective To investigate the response of vaccinated 5ug hepatitis B vaccine to newborns in Zhangqiu City and analyze the influencing factors. Methods A total of 477 infants aged 7 to 12 months who completed the immunization with 5 ug recombinant hepatitis B vaccine in accordance with the national 0,1,6 immunization program were immunoluminated with chemiluminescence microparticle immunoassay (CMIA) and the American Abbott ARCHITECT-i 2000 Detector and its reagents, quantitative detection of hepatitis B virus surface antibodies (anti-HBs). Results The results of 477 neonates showed that the minimum serum anti-HBs titer was 1.14m IU / ml, the maximum was 6 721.36 m IU / ml, and the geometric mean concentration (GMC) was 593.89 m IU / ml. No response rate was 3.14%, low response rate was 23.27%. There was no significant difference between different sexes, full-term birth and children of different birth weight after vaccination (χ ~ 2 = 1.25, P> 0.05; χ ~ 2 = 2.53, P> 0.05) χ ~ 2 = 1.77, P> 0.05). However, the carrier of HbeAg in mothers was related to the low non-response of newborns with hepatitis B vaccine (χ ~ 2 = 9.26, P <0.01). Conclusion The low non-response rate of neonates vaccinated with 5ug recombinant hepatitis B vaccine in Zhangqiu City was 26.42%. The carrying status of mother Hbe Ag has an impact on the immune effect of hepatitis B vaccine.