【摘 要】
：
目的 探讨转录因子基冈在肝再生中的表达变化及作用.方法 经查阅网站资料和相关论文获得转录因子基因及其参与的生理活动,用大鼠基因组230 2.0芯片检测转录因子基因在大鼠再
【机 构】
：
河南省-科技部共建细胞分化调控重点实验室,河南师范大学生命科学学院
【基金项目】
：
国家重点基础研究发展计划(973计划)计划前期研究专项
论文部分内容阅读
目的 探讨转录因子基冈在肝再生中的表达变化及作用.方法 经查阅网站资料和相关论文获得转录因子基因及其参与的生理活动,用大鼠基因组230 2.0芯片检测转录因子基因在大鼠再生肝中的表达,用手术组和假手术组比较的方法确定肝再生相关基因.结果 初步证实上述基因中有320个基因与肝再生相关,涉及细胞代谢、增殖、分化、凋亡等16种生理活动.它们在肝再生中的表达分为41种方式,表明肝再生中细胞生理生化活动具有阶段性、多样性和复杂性.其中,肝再生早期[部分肝切除(PH)后0.5～4h]和前期(PH后6～12h)糖类合成,脂类代谢和炎症反应相关转录因子基因表达增强,中期和后期细胞增殖、生长、分化和凋亡相关转录因子基因表达增强.结论 肝再生的生理生化活动受多种转录因子基因调控.其中,e2f1、fos、copeb等转录因子基因发挥关键作用.
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