基因工程抗体的研究,使人们可以通过基因重组技术获得各种新型的小分子抗体,其中单链抗体具有相对分子质量低、穿透力强、血中半衰期短、抗原结合特异性强、异原性低、容易基因操作、能在原核细胞中表达、易于大量生产等优点,并且可以用化学偶联或基因工程方法构建成与其他靶分子连接的融合蛋白,有利于药物、毒素、放射性同位素导向治疗,因此具有很大的医学应用价值。本文就单链抗体的研究进展及其医学应用作一综述。 Genetic engineering antibodies, so that people can obtain a variety of new recombinant small molecule antibodies, including single-chain antibodies with low relative molecular mass, strong penetration, short blood half-life, antigen-binding specificity, heterologous Low, easy genetic manipulation, can be expressed in prokaryotic cells, easy mass production, etc., and can be chemically coupled or genetically engineered into a fusion protein with other target molecules, is conducive to drugs, toxins, radioisotopes Treatment, it has great medical value. This article reviews the progress of single chain antibodies and their medical applications.