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目的：对乳腺浸润性导管癌神经周浸润与肿瘤的大小、肿瘤的组织学分级、肿瘤的TNM分期、淋巴结转移、5年存活率、肿瘤标志物CEA等之间的关系进行探讨。方法：65例乳腺浸润性导管癌组织常规取材制片，HE、Goden-Sweet网染，laminin、CEA、vimentinS-P法免疫标记染色，光镜观察。结果：神经周浸润与肿瘤大小、肿瘤的组织学分级、肿瘤的TNM分期、淋巴结转移率均成正相关；与淋巴管浸润关系密切，与血管浸润无明显关系；与5年存活率有关，即神经周浸润阳性的5年存活率低于神经周浸润阴性。结论：神经周浸润应作为乳腺浸润性导管癌一种重要的预后参数。神经周浸润阳性的病例，其预后较差。
Objective: To investigate the relationship between perineural invasion of breast infiltrating ductal carcinoma and tumor size, tumor histological grade, tumor TNM stage, lymph node metastasis, 5-year survival rate, and tumor marker CEA. Methods: Sixty-five invasive ductal breast cancer tissues were routinely harvested and stained with HE, Goden-Sweet, and stained with laminin, CEA, and vimentin S-P. Light microscopy was performed. Results: Perineural invasion was positively correlated with tumor size, tumor histological grade, tumor TNM stage, and lymph node metastasis rate. It was closely related to lymphatic infiltration and had no significant relationship with vascular infiltration; it was related to 5-year survival rate, ie nerve Peripheral infiltrating positive 5-year survival is lower than that of perineural infiltration negative. Conclusion: Perineural invasion should be an important prognostic parameter for breast invasive ductal carcinoma. Peritoneal positive cases have a poor prognosis.