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利用心肌细胞耦合模型研究心肌整数倍节律的动力学机理。确定性模型仿真揭示了心肌细胞团同步搏动加周期分岔的节律变化规律;随机模型仿真发现在加周期分岔序列中分岔点附近会出现整数倍节律,其中,0-1整数倍节律产生于从静息到周期1的Hopf分岔点附近,1-2整数倍节律产生于周期1和周期2极限环间的加周期分岔点附近;对系统相空间轨道的分析进一步揭示出整数倍节律是由系统运动在相邻的两个轨道之间随机跃迁形成的。上述分析结果不仅阐明了心肌整数倍节律的机理,并且揭示了各种整数倍节律与加周期分岔序列中相邻节律的内在联系,为重新认识心律变化的规律开辟了新的途径。
Study on the Kinetic Mechanism of Cardiac Integer Rhythm Using Cardiac Cell Coupling Model. Deterministic model simulations revealed rhythms of rhythm of cardiomyocytes with synchronized pulsation and periodic bifurcation. Random model simulation showed that an integral number of rhythms appeared near the bifurcation points in the additive periodic bifurcation sequence. Among them, rhythms 0 to 1 Near the Hopf bifurcation point from rest to period 1, an integer multiple of rhythm 1-2 occurs around the period-bifurcation point between the limit cycles of period 1 and 2; the analysis of the phase space orbit further reveals an integer multiple Rhythms are formed by random movements of system motions between two adjacent tracks. The above analysis not only elucidates the mechanism of integral rhythm of myocardium, but also reveals the inherent relations between various rhythms of multiples and the adjacent rhythms in the periodic addition-bifurcation sequence, which opens up a new way to re-recognize the regularity of rhythm changes.