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目的探讨他汀类降脂药物对有颈动脉斑块形成的高血压患者血压的影响,为临床更好地控制血压、预防心脑血管事件的发生提供依据。方法将74例高血压合并颈动脉斑块形成的患者分为两组,观察组使用阿托伐他汀(立普妥)20 mg/d和苯磺酸氨氯地平(络活喜)5 mg/d,对照组仅使用氨氯地平5 mg/d,观察6个月后进行降压疗效比较。结果观察组收缩压平均下降21.3 mmHg,对照组收缩压平均下降17.2 mmHg,差异有统计学意义(P<0.05),观察组舒张压平均下降7.9 mmHg,对照组舒张压平均下降8.1 mmHg,差异有统计学意义(P<0.05)。结论他汀类降脂药物与氨氯地平合用比单纯应用氨氯地平对高血压合并颈动脉斑块形成的患者降压(尤其是收缩压)效果更好。
Objective To investigate the effect of statins lipid-lowering drugs on blood pressure in hypertensive patients with carotid artery plaque formation, and to provide a basis for better clinical control of blood pressure and prevention of cardiovascular and cerebrovascular events. Methods 74 patients with hypertension and carotid artery plaque were divided into two groups. Atorvastatin (Lipitor) 20 mg / d and amlodipine besylate 5 mg / d, the control group only with amlodipine 5 mg / d, observed after 6 months of antihypertensive efficacy comparison. Results The systolic blood pressure decreased by 21.3 mmHg in the observation group and 17.2 mmHg in the control group (P <0.05), while the diastolic blood pressure decreased by 7.9 mmHg in the observation group and decreased by 8.1 mmHg in the control group Statistical significance (P <0.05). Conclusions The combination of statins and amlodipine is more effective than the simple application of amlodipine in lowering blood pressure (especially systolic blood pressure) in patients with hypertension and carotid plaque formation.