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目的:探讨归脾汤加减辅以西药治疗气虚不摄型消化型溃疡伴出血的临床疗效及机理。方法:选取气虚不摄型中医辨证的消化型溃疡伴出血患者122例,据是否服用中药分为两组,对照组30例,给予三联疗法(奥美拉唑+阿莫西林+克拉霉素);观察组92例,给予归脾汤加减+三联疗法,两组均服药2周,记录并观察比较两组患者平均止血时间,临床中医症状变化及治疗效果。结果:观察组平均止血天数为(3.14±1.21)d,而对照组为(4.51±1.68)d,差异有明显统计学意义(P<0.05),治疗后观察组在胃脘痞满、烧心灼热疼痛、口干、口臭、食欲不振、泛酸嗳气、精神疲乏乏力等症候改善方面明显优于对照组,差异具有统计学意义(P<0.05),观察组临床总有效率为93.48%,高于对照组86.67%,差异明显(P<0.05)。结论:对于气虚不摄型消化型溃疡伴出血患者采用归脾汤加减辅以西药治疗疗效明显优于西药单纯治疗。
Objective: To investigate the clinical effects and mechanism of Guipi Decoction combined with western medicine in treating Qi deficiency without digestive ulcer with bleeding. Methods: A total of 122 patients with digestive ulcer and bleeding who did not take TCM syndrome of Qi deficiency were selected. According to whether taking traditional Chinese medicine was divided into two groups and 30 patients in control group were treated with triple therapy (omeprazole + amoxicillin + clarithromycin) ; Observation group of 92 cases, given Guipi Decoction + triple therapy, both groups were taking 2 weeks, record and observe the average hemostasis time of two groups of patients, clinical symptoms and treatment of traditional Chinese medicine. Results: The average number of days of hemostasis in observation group was (3.14 ± 1.21) d, while in control group (4.51 ± 1.68) d, the difference was statistically significant (P <0.05). After treatment, Pain, dry mouth, bad breath, loss of appetite, pantothenic acid, mental fatigue and other symptoms were significantly better than the control group, the difference was statistically significant (P <0.05), the clinical observation group total effective rate was 93.48% Group 86.67%, the difference was significant (P <0.05). Conclusion: The treatment of Qi deficiency without digestion type peptic ulcer bleeding patients with Guipi Decoction supplemented with western medicine was significantly better than Western medicine alone.