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目的考察热毒宁注射液与临床常用输液配伍后的稳定性。方法利用光阻法测定热毒宁注射液在0.9%氯化钠注射液、5%葡萄糖注射液及10%葡萄糖注射液中的不溶性微粒,采用高效液相色谱法测定热毒宁注射液分别与上述注射液配伍放置8h内栀子苷及绿原酸的含量变化,以及溶液外观和pH值的变化。结果热毒宁注射液与上述3种输液配伍后,微粒数均有不同程度增加,与0.9%氯化钠注射液、5%葡萄糖注射液配伍后8h内pH值以及栀子苷、绿原酸含量均无显著性变化,而与10%葡萄糖溶液配伍4h后pH值及绿原酸含量显著改变(P<0.05)。结论热毒宁注射液与10%葡萄糖注射液不宜配伍,与其余注射液配伍应注意不溶性微粒的问题。
Objective To investigate the stability of Renduining injection combined with common clinical infusion. Methods The thermogravimetric method was used to determine the insoluble particles of Renduining injection in 0.9% sodium chloride injection, 5% glucose injection and 10% glucose injection. Changes in content of geniposide and chlorogenic acid and the appearance and pH of the solution within 8 h after the above injection was placed in compatibility. Results After injection of Rendunning with the above three kinds of transfusion, the number of particles increased in varying degrees, with 0.9% sodium chloride injection, 5% glucose injection 8h after compatibility within the pH and Geniposide, chlorogenic acid (P <0.05). However, pH value and chlorogenic acid content were significantly changed after compatibility with 10% glucose solution for 4h (P <0.05). Conclusion Renduining injection and 10% glucose injection should not be compatible with the rest of the injection compatibility should pay attention to the issue of insoluble particles.