细胞凋亡是细胞生物学行为中一复杂的主动过程,受细胞内外多种因子调控。本文阐述了c-Myc在细胞凋亡中与其它癌基因、抑癌基因bcl-2、p53等产物的相互作用,与蛋白酶类的关系以及与Fas/FasL凋亡途径的偶联。表明c-Myc不仅是促进细胞增殖的重要因子,也是介导细胞凋亡的重要成员。 Apoptosis is a complex and active process in the biological behavior of cells, which is regulated by many factors both inside and outside the cell. This article describes the c-Myc in apoptosis and other oncogenes, tumor suppressor genes such as bcl-2, p53 and other products, the relationship with proteases and Fas / FasL apoptosis pathway coupling. That c-Myc is not only an important factor to promote cell proliferation, but also an important member of apoptosis.