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用离体外翻肠囊法,研究了两类吸收促进剂对氨苄青霉素及利福定肠吸收的影响。发现促进剂的作用与其浓度不成比例,有一最佳浓度范围,其中对氨基水杨酸钠能显著地提高利福定的直肠吸收,体内外相关,生物利用度提高了2.45倍。此外,本文初步探讨了促进剂的作用机制,发现促进剂水杨酸钠的肠通透性与促进作用相关;电泳实验表明促进剂未改变氨苄青霉素的荷电性质,通过测定吸收促进剂作用于肠粘膜后的粘膜静息电位,发现其变化规律与促进剂作用相关。
The effects of two types of absorption enhancers on the absorption of ampicillin and Rifidin were studied by using the eversion valgus method. Found that the role of accelerator and its concentration disproportionate, there is an optimal concentration range, including sodium aminosalicylate can significantly increase the rectal absorption of rifadin, in vitro and in vivo, bioavailability increased by 2.45 times. In addition, this paper preliminary explored the mechanism of action of accelerators and found that the intestinal permeability of the accelerator sodium salicylate was related to the promotion effect. Electrophoresis experiments showed that the accelerators did not change the charging properties of ampicillin, Mucosal resting potential after intestinal mucosa and found that the changes in the law and the role of accelerators.