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目的探讨结肠癌患者可溶性血管细胞粘附分子-1(s VCAM-1)水平变化的意义。方法选择2009年2月至2012年12月间住院的56例结肠癌患者作为研究对象,使用酶联免疫吸附分析(ELISA)方法检测其血清s VCAM-1水平,并与56例门诊健康体检对照组比较。结果结肠癌患者术前及术后各时间点血清s VCAM-1水平均明显高于对照组(均P<0.01)。术后第1、3天血清s VCAM-1水平均明显高于术前(均P<0.01);术后30 d和60 d水平有下降趋势,但仍高于术前(P<0.01和<0.05)。结论血清s VCAM-1水平对结肠癌诊断有一定意义,对于术后疗效的确切作用尚待进一步研究。
Objective To investigate the significance of sVCAM-1 in patients with colon cancer. Methods Fifty-six patients with colon cancer admitted to our hospital from February 2009 to December 2012 were enrolled in this study. Serum s VCAM-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) and compared with 56 outpatients Group comparison. Results The serum levels of VCAM-1 in patients with colon cancer at the preoperative and postoperative time points were significantly higher than those in the control group (all P <0.01). The levels of serum VCAM-1 on the 1st and 3rd postoperative day were significantly higher than those on the preoperative day (all P <0.01), but decreased on the 30th and 60th postoperative days, 0.05). Conclusion Serum VCAM-1 levels have certain significance for the diagnosis of colon cancer, and the exact role of postoperative efficacy remains to be further studied.