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目的：为探讨系统性红斑狼疮（ＳＬＥ）的发病机理，更好地指导临床治疗。方法：我们分析比较了发病年龄＜１８岁、１８～３５岁之间及＞３５岁三个不同年龄组的ＳＬＥ患者临床及血清学特征的异同，并与美国黑人及美国白人ＳＬＥ相比较。结果：发现ＳＬＥ患者中肾脏损害与发病年龄有关，最年轻的病人组有最高的肾损害发生率。随着发病年龄的增大，中枢神经系统及血液系统受累频率增高，但均无显著差异。与美国黑人患者相似，中国汉族ＳＬＥ患者抗体频率均较美国白人高。结论：提示对于发病年龄较小的ＳＬＥ患者要谨防肾脏损害的发生，中国汉族ＳＬＥ自身抗体的分布与美国黑人患者较接近，而与美国白人ＳＬＥ有较大的差异。
Objective: To investigate the pathogenesis of systemic lupus erythematosus (SLE) and to better guide the clinical treatment. METHODS: We analyzed and compared the clinical and serological features of SLE patients at onset age <18 years, 18-35 years and> 35 years of age in comparison to the SLE of African-Americans and white Americans. Results: Kidney damage was found to be related to the age of onset in patients with SLE, and the youngest patient group had the highest incidence of renal damage. As the age of onset increased, the frequency of central nervous system and blood system involvement increased, but no significant difference. Similar to the black patients in the United States, Chinese Han patients with SLE antibody frequency were higher than the white American. CONCLUSIONS: It is suggested that the distribution of SLE autoantibodies in Chinese Han should be close to that of American blacks and to be significantly different from that of white Americans in SLE patients with younger age.