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【目的】分析多同胞是否对儿童哮喘有保护作用。【方法】以2000~2002年德国Wilhelmshaven镇和Delmenhorst镇小学入学儿童为研究对象,共4039人。采用的问卷是国际儿童哮喘与过敏性疾病研究第一阶段问卷的核心问题。同胞数与儿童哮喘关系分别在单变量Logistic回归模型中和多元Logistic回归模型中进行验证。【结果】总的儿童哮喘患病率为12.03%;随着同胞数增加,儿童哮喘患病率下降(P<0.05)。同时,在多元Lo-gistic回归模型中加入家族史和室内暴露因素后,对同胞效应影响小。【结论】儿童哮喘患病率受同胞效应影响,家族史和室内暴露因素对同胞效应无显著影响。
【Objective】 To analyze whether many sibs have a protective effect on childhood asthma. 【Method】 A total of 4039 children were enrolled in primary schools in Wilhelmshaven and Delmenhorst from 2000 to 2002 in Germany. The questionnaire used is a core issue of the first phase of the International Childhood Asthma and Allergic Diseases Questionnaire. The relationship between the number of siblings and childhood asthma was tested in univariate logistic regression model and multivariate logistic regression model respectively. 【Results】 The prevalence of total asthma in children was 12.03%. With the increase of sibs, the prevalence of asthma in children decreased (P <0.05). Meanwhile, adding family history and indoor exposure factors to multivariate Lo-gistic regression model has little effect on sibling effect. 【Conclusion】 The prevalence of childhood asthma is affected by sibling effect. Family history and indoor exposure have no significant effect on sibling effect.