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目的分析广西鼻咽癌高发区初筛2年后鼻咽癌一级亲属和一般人群组血清EB病毒抗体的差异及鼻咽癌发病情况。方法 2013年8~12月广西梧州市、玉林市和南宁市参加鼻咽癌初筛,且2015年8~12月再次接受随访的人群2 022例,对比其初筛时与随访时EB病毒抗体[病毒壳抗原(VCA)-IgA和早期抗原(EA)-IgA]的阳性率,比较鼻咽癌一级亲属(亲属组)和一般人群组中EB病毒抗体的变化及鼻咽癌检出情况。结果初筛时亲属组VCA-IgA阳性率明显高于一般人群组(P<0.05),两组EA-IgA阳性率比较,差异无统计学意义(P>0.05)。亲属组VCA-IgA变化与一般人群组比较,差异有统计学意义(P<0.05);亲属组和一般人群组EA-IgA变化情况,差异无统计学意义(P>0.05)。随访时亲属组VCA-IgA转阴率明显高于一般人群组(P<0.05)。随访时两组VCA-IgA、EA-IgA阳性率比较,差异无统计学意义(P>0.05)。随访时亲属组检出鼻咽癌2例(1.12%),一般人群组检出10例(0.54%),两组的鼻咽检出率比较,差异无统计学意义(P>0.05)。结论初筛后鼻咽癌一级亲属鼻咽癌检出率并未显著高于一般人群组,可能无需选择性随访。
Objective To analyze the difference of serum antibody to Epstein-Barr virus (EBV) and the incidence of nasopharyngeal carcinoma (NPC) among first-degree relatives and general population of nasopharyngeal carcinoma two years after primary screening in high incidence area of nasopharyngeal carcinoma in Guangxi. Methods From January to December 2013, Wuzhou City, Yulin City and Nanning City, Guangxi Province participated in the preliminary screening of nasopharyngeal carcinoma (NPC), and 2,022 patients were interviewed again from August to December in 2015. Compared with the EBV antibody (VCA) -IgA and early antigen (EA) -IgA] were detected by ELISA. The changes of Epstein-Barr virus antibodies in first-degree relatives (relatives) and the general population of NPC were compared with those of nasopharyngeal carcinoma . Results The positive rate of VCA-IgA in the relatives group was significantly higher than that in the general population at the time of screening (P <0.05). There was no significant difference between the two groups in the positive rate of EA-IgA (P> 0.05). The changes of VCA-IgA in relatives were significantly different from those in general population (P <0.05). There was no significant difference in the changes of EA-IgA among relatives and general population (P> 0.05). At follow-up, the negative rate of VCA-IgA in relatives was significantly higher than that in the general population (P <0.05). There was no significant difference in the positive rates of VCA-IgA and EA-IgA between the two groups at follow-up (P> 0.05). There were 2 nasopharyngeal carcinomas (1.12%) in the relatives and 10 (0.54%) in the general population at follow-up. There was no significant difference in nasopharyngeal detection rate between the two groups (P> 0.05). Conclusion The detection rate of nasopharyngeal carcinoma in primary relatives of nasopharyngeal carcinoma after primary screening is not significantly higher than that of general population, and may not require selective follow-up.