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目的探讨长托宁联合呼吸机治疗急性有机磷中毒中间综合征的疗效。方法选取在我院治疗的64例急性有机磷中毒中间综合征的患者,随机分为实验组和对照组,每组32例,实验组给予长托宁联合呼吸机治疗,对照组给予呼吸机治疗,观察2组患者的治愈率、病死率、中毒症状消失时间、肌肉麻痹消失时间的变化情况。结果实验组中毒症状消失时间、肌肉麻痹消失时间分别为(26.3±1.4)h、(23.6±1.8)h;对照组的分别为(29.5±1.2)h、(25.7±1.5)h;2组比较差异有统计学意义(P<0.05);实验组治愈率、病死率分别为93.75%、6.25%;对照组分别为75.00%,25.00%;2组比较差异有统计学意义(P<0.05)。结论应用长托宁联合呼吸机治疗急性有机磷中毒中间综合征患者的疗效较好适于临床上应用。
Objective To investigate the curative effect of the combination of penehyclidine and ventilator in treating intermediate syndrome of acute organophosphate poisoning. Methods Sixty-four patients with intermediate syndrome of acute organophosphate poisoning treated in our hospital were randomly divided into experimental group and control group with 32 cases in each group. The experimental group was treated with penehyclidine and ventilator, while the control group was treated with ventilator The cure rate, fatality rate, disappearance time of poisoning symptom, disappearance time of muscle paralysis in two groups were observed. Results The disappearance time of the symptoms of poisoning and the disappearance of muscle paralysis in the experimental group were (26.3 ± 1.4) h and (23.6 ± 1.8) h, respectively, and (29.5 ± 1.2) and (25.7 ± 1.5) h in the control group respectively The difference was statistically significant (P <0.05). The cure rate and case fatality rate of the experimental group were 93.75% and 6.25% respectively, while those in the control group were 75.00% and 25.00% respectively. There was significant difference between the two groups (P <0.05). Conclusion The application of penehyclidine combined with ventilator in patients with acute organophosphate poisoning syndrome is better for clinical application.