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本文对兔皮肤成纤维细胞进行了体外培养，应用噻唑兰比色法（ＭＴＴ法）对榄香烯和地塞米松进行药物筛选，结果发现：榄香烯对培养的成纤维细胞的增殖具有明显的抑制作用，并使细胞形态发生显著变化，其５０％抑制率浓度（ＩＤ５０）为０．００８ｍｇ／ｍｌ；地塞米松对该细胞增殖的作用呈双重性，低浓度刺激细胞增生，高浓度抑制细胞增殖，其５０％抑制率浓度为１６８ｍｇ／ｍｌ。此两种药物５０％抑制率浓度联合应用，对培养的成纤维细胞增殖的抑制作用（抑制率：６２．８％）较单用榄香烯（抑制率：５２．４％，Ｐ＜０．０１）或单用地塞米松（抑制率：５５．２％ｐ＜０．０１）明显增强。并对此两种药物抗增殖的作用机理进行初步探讨。
In this paper, rabbit skin fibroblasts were cultured in vitro, and elemene and dexamethasone were screened by MTT assay. The results showed that elemene significantly enhanced the proliferation of cultured fibroblasts , And the cell morphology was significantly changed. The 50% inhibitory concentration (ID50) was 0.008 mg / ml. Dexamethasone had a dual effect on cell proliferation. Low concentration stimulated cell proliferation and inhibited high concentration Cell proliferation, the 50% inhibition rate of 168mg / ml. The 50% inhibition rate of the two drugs combined application of the proliferation inhibition of cultured fibroblasts (inhibition rate: 62.8%) than elemene alone (inhibition rate: 52.4%, P <0. 01) or dexamethasone alone (inhibition rate: 55.2% p <0.01). And the two anti-proliferation mechanism of drugs for preliminary study.