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目的:探讨新生儿巨细胞病毒(CMV)感染的影响因素并提出预防措施。方法:对350例孕母脐带血巨细胞病毒抗体及新生儿尿巨细胞病毒DNA检测并收集相关信息进行统计学分析。结果:孕母脐带血抗体阳性的新生儿CMV-DNA感染率较高,达21.62%(P<0.01),并且IgM抗体阳性比IgG抗体阳性的更为显著(Fisher概率确切法P<0.05)。结论:新生儿CMV-DNA感染存在明显的母婴垂直传播现象,近期感染的孕母传播率更高,应着重加强对孕母孕前的诊断治疗和落实孕期的预防措施。
Objective: To investigate the influencing factors of neonatal cytomegalovirus (CMV) infection and to propose preventive measures. Methods: 350 pregnant women with cord blood cytomegalovirus antibodies and neonatal urine cytomegalovirus DNA detection and collection of relevant information for statistical analysis. Results: The positive rate of CMV-DNA in pregnant women with positive cord blood antibodies was 21.62% (P <0.01), and the IgM antibody positive rate was more significant than that of IgG antibody (Fisher probability exact method P <0.05). CONCLUSION: There is a significant vertical transmission of CMV-DNA in newborn infants, and the rate of recent mother-to-mother transmission is higher. Therefore, it is necessary to strengthen the diagnosis and treatment of pregnant women before pregnancy and the preventive measures during pregnancy.