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目的:评价小剂量索他洛尔治疗阵发性心房颤动的疗效和安全性。方法:阵发性房颤患者56例,口服索他洛尔80~160 mg/d分2次口服,观察用药后12周阵发性房颤减少的百分率,24 h平均心率,Q-T间期,Q-T间期离散度(QTd)判定疗效。结果:本组总效率为62.5%,治疗后12周24 h平均心率较前明显降低,Q-T间期较前明显延长,QT d较前明显减少。结论:小剂量索他洛尔预防阵发性房颤的复发和减少发作次数有较好的疗效。
Objective: To evaluate the efficacy and safety of low dose sotalol in the treatment of paroxysmal atrial fibrillation. Methods: 56 patients with paroxysmal atrial fibrillation were orally administered sotalol 80 ~ 160 mg / d orally 2 times. The percentage of paroxysmal atrial fibrillation, mean heart rate at 24 hours, QT interval, QT interval dispersion (QTd) to determine the efficacy. Results: The total efficiency of this group was 62.5%. The mean heart rate at 24 weeks after 12 weeks of treatment was significantly lower than that of the previous period. The Q-T interval was significantly prolonged and the QTd was significantly reduced compared with the previous period. Conclusion: Sotalol is effective in preventing recurrent paroxysmal atrial fibrillation and reducing the number of attacks.