目的脑小血管具有运输血液、调节脑血流、构建血脑屏障等重要作用。当这些血管单元发生病变引起一系列临床事件时称为脑小血管病(CSVD)。在CSVD早期出现血脑屏障通透性增加并持续存在,导致血浆成分从屏障损伤处漏出诱发局部血管及神经细胞损伤。文中对CSVD的血脑屏障损伤及其可能机制进行综述。 Purpose The small blood vessels of the brain have the important functions of transporting blood, regulating cerebral blood flow and building a blood-brain barrier. When these vascular units cause a series of clinical events caused by lesions called cerebrovascular disease (CSVD). In the early stage of CSVD, the blood-brain barrier permeability increases and persists, leading to leakage of plasma components from the barrier injury and inducing local blood vessel and nerve cell damage. The blood-brain barrier injury of CSVD and its possible mechanism are reviewed in this paper.