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目的 :探讨钙拮抗剂地尔硫 艹卓(Diltiazem ,Dil)对失血性休克犬肝、胰、小肠组织的保护作用及机理。方法 :犬股动脉放血 ,平均动脉压 (meanarterypressure,MAP)降至 5 33- 6 .6 7kPa(4 0 - 5 0mmHg) ,分别输Dil和生理盐水。休克 90min时将放出的血液全部回输。整个实验观察 2 40min。结果 :从 15 0min到 2 40min ,Dil明显提高MAP(P <0 0 1) ;降低肝、胰、小肠组织中丙二醛 (malondialdehyde ,MDA)含量 (P <0 .0 1) ;胰腺组织超氧化物歧化酶 (SOD)活性升高。电镜显示 :使用Dil后 ,休克犬肝、胰、小肠组织结构正常。结论 :在犬失血性休克中 ,钙拮抗剂Dil能保护肝、胰、小肠组织结构和功能的完整性
Objective: To investigate the protective effect and mechanism of Diltiazem (Dil), a calcium antagonist, on liver, pancreas and small intestine in hemorrhagic shock dogs. Methods: Canine femoral artery was exsanguinated and mean arterial pressure (MAP) was reduced to 53.6-6.7 kPa (40-50 mmHg). Dil and saline were respectively administered. Shock 90min will release all the blood back to lose. The entire experimental observation 2 40min. Results: Dil significantly increased MAP (P <0.01), reduced malondialdehyde (MDA) content in liver, pancreas and small intestine from 150 min to 240 min (P <0.01) Oxide dismutase (SOD) activity increased. Electron microscope showed: After using Dil, shock dogs liver, pancreas, small intestine tissue structure is normal. CONCLUSIONS: Dil, a calcium antagonist, protects the integrity of liver, pancreas and small intestine tissue structure and function in hemorrhagic shock in dogs