自从1932年美国医师Crohn等首次描述了一种肠道慢性肉芽肿性疾病——克隆病(Crobn’sdisease)以来,该病的病因问题就一直困扰着众多的研究者.虽有遗传、环境、感染及免疫等病因学说.似均难以解释疾病的发生及全貌.迄今公认的是免疫活化在发病学中肯定有作用,但似乎不是始动原因而多系一中介过程. 确切的始动原因尚无定论.不过,分支杆菌作为一种可能的始动原因,已越来越受到重视.其实,早在本世纪初人们就发现克隆病与肠结核在临床表现和病理改变上有许多相似性,因而联想到分支杆菌与其发病可能有关.并为此进行了不懈地探索. The etiology of the disease has plagued many researchers since Crohn’s disease, an intestinal chronic granulomatous disease, was first described by Crohn et al in 1932. Although genetic, environmental, Infection and immune etiology, etc. It seems difficult to explain the occurrence and picture of the disease has so far been recognized as immune activation in the pathogenesis of a certain role, but it seems not to start the reason and more than an intermediary process. However, Mycobacterium as a possible starting reason, more and more attention has been paid.In fact, as early as the beginning of this century, people have found that Crohn’s disease and intestinal tuberculosis in clinical manifestations and pathological changes have many similarities, So think of mycobacterium may be related to its pathogenesis, and has made unremitting efforts to explore this.