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目的研究再生基因蛋白Ⅳ(RegⅣ)及表皮生长因子受体(EGFR)在大肠癌中的表达及其临床意义。方法应用S-P免疫组化技术检测57例大肠癌及其相应的癌旁正常组织中RegⅣ和EGFR的表达。结果 57例大肠癌组织中RegⅣ、EGFR的阳性表达率均高于癌旁正常组织,差异具有统计学意义。RegⅣ与EGFR在大肠癌组织中的表达呈正相关关系。结论 RegⅣ可能通过激活EGFR/PI3K/Akt信号系统在肿瘤的发生发展中发挥重要作用。
Objective To investigate the expression and clinical significance of RegIV and EGFR in colorectal cancer. Methods Immunohistochemical technique of S-P was used to detect the expression of Reg IV and EGFR in 57 cases of colorectal cancer and their corresponding adjacent normal tissues. Results The positive rates of RegIV and EGFR in 57 cases of colorectal cancer were higher than those in adjacent normal tissues. The difference was statistically significant. There is a positive correlation between the expression of RegIV and EGFR in colorectal cancer. Conclusion RegIV may play an important role in tumorigenesis and development by activating EGFR/PI3K/Akt signaling system.