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目的分析儿童EB病毒感染临床表现、实验室特点及治疗效果。方法 2006年9月至2009年9月在本溪中心医院诊断为EB病毒感染的患儿96例,男62例,女34例。均经临床表现、咽拭子EB病毒DNA(EBVDNA)检测及影像改变综合分析、明确诊断。治疗方法采取口服阿昔洛韦或静脉滴注更昔洛韦,并适当配合应用干扰素、痰热清、热毒宁等。结果 EB病毒感染发病时季节集中在9～11月,男女比例为1.8∶1。所有病例经治疗全部治愈出院,住院时间5～19d。结论儿童EB病毒感染临床表现复杂,缺乏特异表现,重者可危及生命,应增强对该感染的认识,力求及时诊断、及时用药,阻断病毒对儿童的伤害。更昔洛韦能安全有效地治疗儿童EB病毒感染,很少出现不良反应。
Objective To analyze the clinical manifestations, laboratory characteristics and therapeutic effects of Epstein-Barr virus in children. Methods 96 patients with Epstein-Barr virus (EBV) infection were diagnosed in Benxi Central Hospital from September 2006 to September 2009, including 62 males and 34 females. All clinical manifestations, throat swab EBV DNA (EBVDNA) detection and comprehensive analysis of changes in the image, a clear diagnosis. Treatment of oral acyclovir or intravenous ganciclovir, and the appropriate use of interferon, Tanreqing, Renduine and so on. Results The incidence of Epstein-Barr virus infection concentrated in the season from September to November, the male-female ratio was 1.8: 1. All cases were cured after treatment were discharged, hospitalization time 5 ~ 19d. Conclusion The clinical manifestations of EBV infection in children are complex and lacks specific performance. In severe cases, it can be life-threatening. The awareness of EBV infection should be enhanced so as to promptly diagnose and promptly take medication to prevent the virus from harming children. Ganciclovir can safely and effectively treat children with Epstein-Barr virus infection with few adverse reactions.