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肾脏排泄功能检查,项目较多,临床上常用而普遍检查的是测定血肌酐(SCr)和尿素氮(BUN)。Cr为内源性代谢产物,由肌肉代谢产生,从肌酸转化而来,其产生速率比较恒定,约1mg/分。正常肾脏也以同样速度排除。故正常人Cr的含量为0.5～1.5mg%血浆或血清。Cr由肾小球滤过后不再被肾小管吸收。在血浆含量接近正常时,肾小管亦不分泌Cr,并不受饮水量、蛋白摄入量、胃肠道出血、和肝功能影响。而血BUN或非蛋白氮(NPN)浓度,常受上述因素及发热、感染、某些药物(四环素、激素)等影响,因此,可靠性较差。内生肌酐清除率(Ccr)是体内组织代谢产生的Cr,它不受上述因素的影响。故目前认为Ccr是检测肾小球滤过率(GFR)最敏感、最可靠的指标。成人Ccr的正常值为80～120ml/min,低于8(?)ml/min表示GFR下降。但由于在检测上仍有一定
Kidney excretion function test, the project more commonly used in clinical practice is the determination of serum creatinine (SCr) and urea nitrogen (BUN). Cr is an endogenous metabolite that is produced by muscle metabolism and is converted from creatine at a relatively constant rate of about 1 mg / min. Normal kidneys are also excluded at the same rate. Therefore, the normal content of Cr 0.5 ~ 1.5mg% plasma or serum. Cr is no longer absorbed by the tubules after it has been filtered by glomerular filtration. At plasma levels close to normal, tubules also do not secrete Cr, irrespective of water intake, protein intake, gastrointestinal bleeding, and liver function. Blood BUN or non-protein nitrogen (NPN) concentrations, often affected by the above factors and fever, infection, certain drugs (tetracycline, hormones) and so on, so the reliability is poor. Endogenous creatinine clearance (Ccr) is the body tissue metabolism of Cr, it is not affected by the above factors. Therefore, Ccr is currently considered the most sensitive and reliable indicator of glomerular filtration rate (GFR). Adult Ccr normal value of 80 ~ 120ml / min, less than 8 (?) Ml / min GFR decreased. However, due to the detection is still a certain