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目的:比较盐酸氨溴索2种含量测定方法。方法:用紫外分光光度法和高效液相色谱法分别测定盐酸氨溴索的含量,并对这2种测定方法进行了比较。结果:在稳定性实验和含量测定过程中,同一样品用高效液相色谱法测定的RSD均值为0.86%和1.27%,用紫外分光光度法测定的均值为1.40%和1.80%;用高效液相色谱法测定盐酸氨溴索的含量,其RSD值前者小于后者,结果更为准确。结论:高效液相色谱法测定盐酸氨溴索的含量优于紫外分光光度法,且稳定性好,准确性高。
Objective: To compare two methods of determination of ambroxol hydrochloride. Methods: The content of ambroxol hydrochloride was determined by UV spectrophotometry and high performance liquid chromatography respectively. The two methods were compared. Results: In the stability test and determination of contents, the average RSD of the same sample measured by high performance liquid chromatography was 0.86% and 1.27%, the average of 1.40% and 1.80% measured by UV spectrophotometry; Determination of ambroxol hydrochloride content by chromatography, the former RSD value is less than the latter, the result is more accurate. Conclusion: The determination of ambroxol hydrochloride by HPLC is superior to UV spectrophotometry, with good stability and high accuracy.