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目的探讨恶性皮肤角质形成细胞肿瘤中 p27、细胞周期素 D1的蛋白表达与角质形成细胞肿瘤的关系。方法用免疫组化法检测肿瘤细胞 p27与细胞周期素 D1蛋白表达。结果 p27在 Bowen病和日光性角化病均为高表达，基底细胞癌和鳞状细胞癌为低表达，而且前两者的表达显著高于后两者（ P< 0.05）。细胞周期素 D1在 Bowen病、基底细胞癌及日光性角化病均无表达，而在鳞状细胞癌表达率很高。结论 p27和细胞周期素 D1蛋白表达在皮肤角质形成细胞肿瘤中的改变具有一定肿瘤特异性，可作为判断角质形成细胞肿瘤恶性程度、评估预后的指标。
Objective To investigate the relationship between p27 and cyclin D1 protein expression and keratinocyte tumor in malignant keratinocyte tumors. Methods The expression of p27 and cyclin D1 protein in tumor cells was detected by immunohistochemistry. Results p27 was highly expressed in Bowen’s disease and solar keratoses. Basal cell carcinoma and squamous cell carcinoma had low expression of p27. The expression of p27 was significantly higher than that of the latter two (P<0.05). Cyclin D1 was not expressed in Bowen’s disease, basal cell carcinoma and solar keratosis, but was highly expressed in squamous cell carcinoma. Conclusion The changes of p27 and cyclin D1 protein expression in keratinocyte tumors of the skin have certain tumor specificity and can be used as indicators for judging the malignant degree of keratinocyte tumors and evaluating the prognosis.