当三环抗抑郁剂以治疗量使用时,肌阵挛是此类药“罕见”的并发症。与此相反,本文发现用丙咪嗪常规剂量治疗的患者也出现肌阵挛。本文目的就是研究此类药物所致肌阵挛的发生率和追踪观察。研究对象为93例重性抑郁症和5例惊恐障碍患者。口服丙咪嗪从50mg/日(或等量的其它抗抑郁剂)开始,以后逐渐增大至300mg/日。治疗的第2、4、8周进行肌阵挛症状评定。肌阵挛的定义为一种不自主的、不规则的肌肉和肌群收缩。有抽搐、震颤、共济失调、帕金森氏病、TD、舞蹈-手指 When tricyclic antidepressants are used in therapeutic doses, myoclonus is a “rare” complication of such drugs. In contrast, we found that patients treated with conventional doses of imipramine also developed myoclonus. The purpose of this article is to study the incidence of myoclonus caused by such drugs and follow-up observation. The subjects were 93 patients with major depression and 5 patients with panic disorder. Oral imipramine starts with 50 mg / day (or equivalent of other antidepressants) and then gradually increases to 300 mg / day. The 2nd, 4th, and 8th weeks of treatment were evaluated for myoclonus symptoms. Myoclonus is defined as an involuntary, irregular muscle and muscle contraction. Have convulsions, tremor, ataxia, Parkinson’s disease, TD, dance - fingers