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目的 :探讨内皮素 (ET) 1和一氧化氮 (NO)在蛛网膜下腔出血 (SAH)后脑血管痉挛 (CVS)及脑缺血性损害中的作用。方法 :采用非开颅法大鼠SAH模型 ,检测 2 4h内血及脑组织中NO和ET 1含量 ,并测定脑微区血流 (rCBF)和基底动脉管径。结果 :大鼠SAH后 30min基底动脉管径缩小 ,rCBF持续下降 ;血NO减少 ,ET 1增多 ;脑组织NO和ET 1均增加。结论 :血NO减少 ,ET增多系SAH后CVS发生的原因之一 ;脑组织NO和ET增多则加重脑损伤
Objective: To explore the role of endothelin (ET) 1 and nitric oxide (NO) in cerebral vasospasm (CVS) and cerebral ischemic damage after subarachnoid hemorrhage (SAH). Methods: The SAH model of non-craniotomy rats was used to detect the content of NO and ET 1 in blood and brain tissue within 24 hours. The blood flow of cerebral micro-regions (rCBF) and the diameter of basilar artery were measured. Results: The diameter of basilar artery shrank 30 minutes after SAH in rats, and the rCBF decreased continuously. The levels of NO and ET 1 increased while NO and ET 1 increased. Conclusion: The decrease of serum NO and the increase of ET are one of the causes of CVS after SAH. The increase of NO and ET in brain tissue aggravate brain injury