论文部分内容阅读
目的探讨绝经女性中心型肥胖与血脂异常的关系。方法依据苏州工业园区2014年慢性病社区综合防治项目,随机抽取某社区2 000名居民,选取其中健康自然绝经12个月以上的女性323人,测量身高、体重、腰围、血压,采血测甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)水平。根据卫生行业标准《成人体重判定》,腰围≥85 cm诊断为中心型肥胖,根据《中国成人血脂异常防治指南(2007)》中TG、TC、HDL-C和LDL-C的水平诊断血脂异常。采用多因素Logistic回归分析中心型肥胖与血脂异常发病风险之间的关系。结果该绝经女性人群中心型肥胖占13.6%(44/323),血脂异常检出率为29.7%(96/323),中心型肥胖组血脂异常检出率显著高于正常组(43.2%vs 27.6%,P=0.036)。腰围水平与TG及LDL-C呈正相关(TG:r=0.28,P<0.01;LDL-C:r=0.20,P<0.01),与HDL-C呈负相关(r=-0.26,P<0.01)。多因素Logistic回归分析显示中心型肥胖组患血脂异常的OR值为2.07(95%CI 1.04~4.13,P=0.039),其中中心型肥胖组TG升高和HDL-C降低的OR值分别为3.81(95%CI1.69~8.60,P=0.001)和3.19(95%CI 1.36~7.52,P=0.008)。结论中心型肥胖是绝经女性血脂异常的危险因素。
Objective To investigate the relationship between central obesity and dyslipidemia in postmenopausal women. Methods Based on the 2014 comprehensive program of chronic diseases prevention and control in Suzhou Industrial Park, we randomly selected 2,000 residents in a certain community and selected 323 healthy women with natural menopause for 12 months or more. Height, weight, waist circumference, blood pressure, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDLC). According to the health industry standard “adult weight determination”, waist circumference≥85 cm was diagnosed as central obesity, and dyslipidemia was diagnosed according to the levels of TG, TC, HDL-C and LDL-C in the Guideline for Prevention and Treatment of Dyslipidemia in Chinese Adults (2007). Multivariate Logistic regression analysis of the relationship between central obesity and the risk of dyslipidemia. Results The prevalence of central obesity was 13.6% (44/323) and the prevalence of dyslipidemia was 29.7% (96/323). The prevalence of dyslipidemia in central obesity group was significantly higher than that in the normal group (43.2% vs 27.6% %, P = 0.036). The waist circumference was positively correlated with TG and LDL-C (TG: r = 0.28, P <0.01; LDL-C: r = 0.20, P <0.01) ). Multivariate logistic regression analysis showed that the OR of dyslipidemia in central obesity group was 2.07 (95% CI 1.04-4.13, P = 0.039). The OR values of TG elevation and HDL-C reduction in central obesity group were 3.81 (95% CI 1.69-8.60, P = 0.001) and 3.19 (95% CI 1.36-7.52, P = 0.008). Conclusions Central obesity is a risk factor for dyslipidemia in postmenopausal women.