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为观察垂体腺瘤患者围术期促肾上腺皮质激素 (ACTH)与皮质醇 (COR)的变化 ,选取 2 8例择期脑瘤切除患者 ,分为非垂体瘤组 (Ⅰ组 ,n =7)、生长激素 (GH)升高垂体瘤组 (Ⅱ组 ,n =9)和泌乳素升高垂体瘤组 (Ⅲ组 ,n =1 2 ) ,采用静吸复合全麻。抽取围术期不同阶段的静脉血标本 ,用放免法检测ACTH及COR。结果显示 ,术毕停麻醉2 0min时的ACTH和COR与入院后基础值相比差异显著 (P <0 .0 5) ,且Ⅱ、Ⅲ组与Ⅰ组间差异显著 (P <0 .0 5)。提示 :垂体腺瘤患者术毕时ACTH及COR水平明显高于术前 ,这不同于其他神经外科患者。
To observe the changes of perioperative adrenocorticotropic hormone (ACTH) and cortisol (COR) in patients with pituitary adenoma, 28 patients with elective brain tumor resection were enrolled and divided into non-pituitary tumor group (n = 7) Growth hormone (GH) was elevated in the pituitary tumor group (group Ⅱ, n = 9) and in the prolactin-increased pituitary tumor group (group Ⅲ, n = 12). Venous blood samples were collected at different stages of perioperative period and ACTH and COR were detected by radioimmunoassay. The results showed that ACTH and COR at 20 min after operation and stop were significantly different from baseline values after admission (P <0.05), and there was significant difference between group Ⅱ and Ⅲ and group Ⅰ (P0.05 ). Tip: Pituitary adenoma patients at the end of surgery ACTH and COR levels were significantly higher than preoperative, which is different from other neurosurgical patients.