60例急性缺氧豚鼠心律失常的分析

来源 :首都医学院学报 | 被引量 : 0次 | 上传用户:
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急性心肌缺氧、缺血时,无论在动物或人体均可出现心律失常,关于这些心律失常的类型因种族、机能状态不同存在很大差异,但不外乎是自律性异常及传导障碍两大类。为了正确认识各种动物在急性缺氧条件下心律失常的表现形式,我们首先将60例在体缺氧豚鼠的心律失常总结如下。1 材料和方法应用本院动物室饲养的健康豚鼠60只,按完全随机抽样原则,雄55例,雌5例,雄雌之比11:1,体重400~700g。实验动物在乌拉坦(20%,6ml/kg)麻醉下做气管插管,用室内空气进行正压人工呼吸后,应用XDH-3型心电图机描记标准肢体Ⅱ导心电图(1mV=20mm;纸速为25mm/s)。观察5min。然后由呼吸机吸入预先用LML-Ⅱ型湿式气体流量计按不同氧氮比例(21%、10%、5‰、2%氧及纯 Acute myocardial hypoxia, ischemia, both in animals or humans can arrhythmia, the type of arrhythmia due to race, different functional status there is a big difference, but nothing more than a self-regulatory abnormalities and conduction disorders two class. In order to correctly understand the various forms of arrhythmia in acute hypoxia, we first summarize the arrhythmia in 60 hypoxic guinea pigs as follows. 1 Materials and Methods 60 healthy guinea pigs were housed in the animal room of our hospital. According to the principle of completely random sampling, there were 55 males and 5 females. The ratio of male to female was 11: 1 and the weight was 400-700g. The experimental animals were anesthetized with urethane (20%, 6ml / kg) for tracheal intubation. After positive air pressure artificial respiration with indoor air, the standard limb Ⅱ-lead electrocardiogram (1mV = 20mm; 25 mm / s). Observation 5min. Then inhaled by the ventilator pre-LML-Ⅱ type wet gas flow meter according to the different ratio of oxygen and nitrogen (21%, 10%, 5 ‰, 2% oxygen and pure
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