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目的探讨原发性高血压患者血压变异性及血压昼夜节律与颈动脉粥样硬化的关系。方法运用24h动态血压监测(ABPM)对入选的84例高血压患者进行监测,同时根据颈动脉彩超检查结果将其分为硬化组(38例)和非硬化组(46例),对比分析两组动态血压参数。结果①硬化组24 h、白昼、夜间的收缩压(SBP)、脉压(PP)、血压变异性(SSD、DSD)及颈动脉内膜中层厚度(IMT)均明显高于非硬化组,差异具有统计学意义(P<0.05或P<0.01);②硬化组的非杓型血压检出率高于非硬化组,差异有统计学意义(P<0.05)。结论高血压患者血压变异性及血压昼夜节律与颈动脉粥样硬化密切相关。
Objective To investigate the relationship between variability of blood pressure and circadian rhythm of blood pressure and carotid atherosclerosis in patients with essential hypertension. Methods Eighty-four patients with hypertension were monitored by ABPM. According to the results of carotid ultrasonography, they were divided into sclerotic group (38 cases) and non-sclerotic group (46 cases) Dynamic blood pressure parameters. Results ① SBP, PP, SSD, DSD and carotid intima-media thickness (IMT) in sclerosis group at 24 h were significantly higher than those in non-sclerosis group at 24 h (P <0.05 or P <0.01). ② The detection rate of non-dipper blood pressure in sclerosis group was higher than that in non-sclerosis group, the difference was statistically significant (P <0.05). Conclusion The variability of blood pressure and the circadian rhythm of blood pressure are closely related to carotid atherosclerosis.