论文部分内容阅读
苦皮藤素 是从杀虫植物苦皮藤 (Celastrus angulatus Max)根皮提取物中分离得到的对昆虫有毒杀活性的一种新化合物。通过对该化合物引起粘虫产生类似神经毒剂兴奋性症状的机理研究 ,结果表明 ,苦皮藤素 对昆虫中枢神经系统兴奋性突触后电位(EPSP)和轴突动作电位 (AP)无显著影响 ;试虫经苦皮藤素 处理后 ,抽搐期和失水期体内乙酰胆碱酯酶 (ACh E)活性分别下降 33.9%和 39.6% ,谷氨酸 (Glu)含量分别升高 2 8.44%和 49.1 8% ,γ-氨基丁酸 (GABA)含量分别降低 42 .1 1 %和 44.47%。抽搐期体内谷氨酸脱羧酶活性降低了 8.67%。
Celangulin is a new compound isolated from the root bark of the insecticidal plant Celastrus angulatus Max and is toxic to insects. The results showed that cephornin had no significant effect on excitatory postsynaptic potential (EPSP) and axon action potential (AP) of insect central nervous system . The activity of acetylcholinesterase (AChE) decreased by 33.9% and 39.6% respectively in the seizure and dehydration stages after treatment with cepharanthine, while the glutamic acid (Glu) content increased by 2 8.44% and 49.1 8, respectively %, γ-aminobutyric acid (GABA) content decreased by 42.1% and 44.47% respectively. Twitch phase in vivo glutamate decarboxylase activity decreased by 8.67%.